A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/07 (2006.01) A01N 63/00 (2006.01) A61K 31/70 (2006.01) A61K 35/74 (2006.01) A61K 38/00 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) C07K 14/335 (2006.01) C12P 19/00 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2378620
Strains of Lactobacilli having the ability to reduce or block pro-inflammatory cytokines and also to induce anti-inflammatory cytokines are disclosed. These strains may be used to prepare therapeutic agents that reduce inflammation. Lactobacillus secreted proteins, carbohydrates and lipids are also disclosed. The Lactobacillus secretions, which block translocation of bacterial agents such as Gram (-) bacteria, other infectious agents, toxins, chemicals and injurious substances, may be used in the prevention and treatment of inflammation caused by bacterial translocation and injury and in treating gastrointestinal dysfunctions.
L'invention concerne des souches de Lactobacilli capables de réduire ou de bloquer des cytokines pro-inflammatoires, et de produire des cytokines anti-inflammatoires. Ces souches peuvent être utilisées dans la préparation d'agents thérapeutiques destinés à réduire les inflammations. L'invention concerne également des protéines, des glucides et des lipides sécrétés par le Lactobacillus. Les sécrétions du Lactobacillus bloquant la translocation d'agents bactériens tels que la bactérie Gram négative, d'autres agents infectieux, de toxines, et de substances néfastes, peuvent être utilisées dans la prévention et le traitement des inflammations causées par translocation bactérienne et par blessure, et dans le traitement des dysfonctionnements gastro-intestinaux.
Borden Ladner Gervais Llp
University Of Maryland Baltimore
LandOfFree
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