Pro-oxidant anti-cancer compounds

Details Pro-oxidant anti-cancer compounds Pro-oxidant anti-cancer compounds

C - Chemistry, Metallurgy

12

N

C12N 9/02 (2006.01) A61K 31/355 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/26 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2663474

This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In particular, the invention concerns pro-oxidant anti-cancer compounds, such as pro-oxidant forms of vitamin E, that selectively interact with complex II of the mitochondrial respiratory chain of cancerous cells, generate reactive oxygen species and induce apoptosis of those cells.

Cette invention concerne des composés anti-cancer et des procédés pour traiter ou prévenir le cancer. En particulier, l'invention concerne des composés anti-cancer pro-oxydants, tels que des formes pro-oxydantes de la vitamine E, qui interagissent sélectivement avec le complexe II de la chaîne respiratoire mitochondriale des cellules cancéreuses, génèrent des espèces d'oxygène réactives et induisent l'apoptose de ces cellules.

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