Pro104 antibody compositions and methods of use

Details Pro104 antibody compositions and methods of use Pro104 antibody compositions and methods of use

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01) G01N 33/563 (2006.01) G01N 33/58 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2530605

The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro 104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Prol04 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro 104 antibody, as well as an expression vector comprising the isolated'l nucleic acid. Also provided are cells that produce the anti-Pro 104 antibodies. The invention encompasses a method of producing the anti-Pro l04 antibodies. Other aspects of the invention are a method of killing a Pro 104-expressing cancer cell, comprising contacting the cancer cell with an anti~Prol04 antibody and a method of alleviating or treating a Pro 104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro 104 antibody to the mammal.

L'invention concerne des anticorps de l'antigène (Pro104) isolé, anti-ovarien, pancréatique, du cancer du poumon ou du sein qui se lie au Pro104 sur une cellule mammifère in vivo. L'invention concerne également des compositions comprenant un anticorps anti-Pro104 et un vecteur. Lesdites compositions peuvent être situées dans un article de fabrication ou un kit. Dans un autre aspect de l'invention, un acide nucléique isolé codant un anticorps anti-Pro104 est utilisé, ainsi qu'un vecteur d'expression comprenant ledit acide nucléique isolé. L'invention concerne également des cellules produisant les anticorps anti-Pro104, ainsi qu'un procédé de production desdits anticorps anti-Pro104. Dans d'autres aspects de l'invention, un procédé permet de tuer une cellules cancéreuse exprimant un Pro104, et il comprend la mise en contact de la cellule cancéreuse avec un anticorps anti-Pro104. L'invention concerne également un procédé pour atténuer ou traiter un cancer exprimant un Pro104 chez un mammifère, comprenant l'administration d'une quantité efficace thérapeutiquement de l'anticorps anti-Pro104 à un mammifère.

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