C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 31/7088 (2006.01) A61K 35/48 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/104 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/21 (2006.01) C07K 14/325 (2006.01) C07K 14/33 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2457903
Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, The proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.
L'invention concerne des peptides de proaérolysine (PA) modifiés. Dans certains modes de réalisation, ces protéines comprennent un site de clivage de protéase spécifique de la prostate et peuvent également comprendre un domaine de liaison spécifique du tissu de la prostate remplaçant dans son fonctionnement le domaine de liaison PA d'origine. Dans d'autres modes de réalisation, ces protéines comprennent un site de clivage de furine et un domaine de liaison spécifique du tissu de la prostate remplaçant dans son fonctionnement le domaine de liaison PA d'origine. L'invention concerne également des procédés mettant en oeuvre de tels peptides pour traiter le cancer de la prostate.
Buckley James Thomas
Denmeade Samuel R.
Isaacs John T.
Innovation And Development Corporation University Of Victoria
Johns Hopkins University
Smart & Biggar
LandOfFree
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