Probiotic compounds from lactobacillus gg and uses therefor

Details Probiotic compounds from lactobacillus gg and uses therefor Probiotic compounds from lactobacillus gg and uses therefor

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) A61K 35/74 (2006.01)

Patent

CA 2563702

The invention provides methods and compositions for the treatment of inflammatory disorders, such as inflammatory bowel diseases (IBDs). The use of bacteria-free, probiotic-derived compounds instead of live bacteria provides a safety advantage over the use of live bacteria. In addition, the clinical efficacy of isolated compounds has been shown to be more consistent than for probiotics, which depend on the ability to establish and maintain bacterial colonization.

L'invention fournit des procédés et des compositions pour le traitement de troubles inflammatoires, tels que des maladies inflammatoires intestinales (IBD). L'utilisation de composés exempts de bactéries dérivés de probiotiques à la place de bactéries vivantes fournit un avantage en termes de sécurité par rapport à l'utilisation de bactéries vivantes. En plus, il a été montré que l'efficacité clinique des composés séparés était plus régulière que celle de probiotiques, laquelle dépend de l'aptitude à établir et à maintenir une colonisation bactérienne.

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