Probiotic lactobacillus casei strains

Details Probiotic lactobacillus casei strains Probiotic lactobacillus casei strains

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 35/74 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2454805

A Lactobacillus casei strain or a mutant or variant thereof isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. In particular a Lactobacillus casei strain, AH101, AH104, AHlll, AHl12 or AHl13 or mutants or variants are thereof are useful in the prophylaxis and/or treatment of inflammatory activity especially undesirable gastrointestinal inflammatory activity, such as inflammatory bowel disease or irritable bowel syndrome.

L'invention concerne une souche de Lactobacillus casei, ou un mutant ou un variant correspondant, isolée à partir d'un tractus gastro-intestinal humain réséqué et lavé, cette souche étant fortement immunomodulatrice chez l'homme après une ingestion par voie orale. Plus particulièrement, les souches de Lactobacillus casei, soit AH101, AH104, AH111, AH112 ou AH113, ou des mutants ou des variants correspondants, sont utiles dans la prévention et/ou le traitement d'une activité inflammatoire, et notamment d'une activité inflammatoire gastro-intestinale indésirable telle que la maladie intestinale inflammatoire ou le syndrome du côlon irritable.

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