Probiotic oral dosage forms

Details Probiotic oral dosage forms Probiotic oral dosage forms

A - Human Necessities

23

L

A23L 1/30 (2006.01) A61K 9/20 (2006.01) A61K 35/74 (2006.01)

Patent

CA 2664583

Provided are probiotic compositions that have enhanced stability under various storage conditions. The stability of the probiotic compositions is enhanced through the addition of various agents and excipients. Examples of agents and excipients that may be used to enhance the stability of probiotic compositions include prebiotics, such as the sugar alcohols mannitol, sorbitol, and lactitol, and/or phytonutrients such as oligomeric proanthocyanidins (OPCs). The probiotic compositions may be formulated into oral dosage forms such as tablets, caplets, and capsules, or manufactured as a chewing gum or as a powder formulation that may be dissolved in a liquid such as water, milk, juice, or yogurt.

L'invention concerne des compositions probiotiques présentant une stabilité accrue dans des conditions de stockage diverses. La stabilité de ces compositions probiotiques est accrue par l'ajout de divers agents et excipients. Des exemples d'agents et d'excipients aptes à accroître la stabilité de ces compositions comprennent des prébiotiques, tels que des alcools de sucre - le mannitol, le sorbitol et le lactitol - et/ou des phytonutriments tels que des proanthocyanidines oligomères (OPC). Les compositions selon l'invention peuvent être préparées sous forme de doses orales telles que des comprimés, des comprimés-capsules et des capsules, ou de gomme à mâcher ou de poudre à dissoudre dans un liquide tel que de l'eau, du lait, du jus ou du yaourt.

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