Probiotic strain and antimicrobial peptide derived therefrom

Details Probiotic strain and antimicrobial peptide derived therefrom Probiotic strain and antimicrobial peptide derived therefrom

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 35/74 (2006.01) A61K 38/16 (2006.01) A61P 31/04 (2006.01) C07H 21/00 (2006.01) C07K 14/315 (2006.01) C07K 17/08 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2647161

The invention relates to a strain of Enterococcus mundtii having probiotic qualities. The strain of E. mundtii (ST4SA) produces an antimicrobial peptide which exhibits antimicrobial activity against a broad range of bacteria. The invention also provids an isolated nucleotide sequence which codes for the antimicrobial peptide (peptide ST4SA). Another aspect of the invention relates to a process for the production of a peptide of the invention which comprises cultivating Enterococcus mundtii strain ST4SA in a nutrient medium under micro-aerophilic conditions at a temperature of between 100C and 45°C, until a recoverable quantity of said peptide is produced, and recovering said peptide. The isolated peptide of the invention may be used as an antimicrobial agent in a liquid formulation or a gel formulation as a topical treatment and may also be used as an antimicrobial agent following encapsulation in a polymer.

L'invention concerne une souche d'Enterococcus mundtii ayant des qualités probiotiques. La souche d'E. mundtii (ST4SA) produit un peptide antimicrobien qui présente une activité antimicrobienne contre un large spectre de bactéries. L'invention concerne également une séquence nucléotidique isolée codant pour ledit peptide antimicrobien (peptide ST4SA). Sous un autre aspect, l'invention concerne un procédé de production d'un peptide de l'invention impliquant de cultiver la souche ST4SA d'Enterococcus mundtii dans un milieu nutritif dans des conditions micro-aérophiles, à une température comprise entre 100 °C et 45 °C, jusqu'à obtention d'une quantité récupérable dudit peptide, puis à récupérer ledit peptide. Le peptide isolé de l'invention peut être utilisé en tant qu'agent antimicrobien dans une formulation liquide ou de gel utilisée comme traitement topique ; il peut également être utilisé en tant qu'agent antimicrobien après encapsulation dans un polymère.

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