C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A23C 9/12 (2006.01) A23L 1/03 (2006.01) A61K 35/74 (2006.01) C07K 14/335 (2006.01)
Patent
CA 2280704
A strain of Lactobacillus salivarius isolated from resected and washed human gastrointestinal tract inhibits a broad range of Gram positive and Gram negative microorganisms and secretes a product having antimicrobial activity into a cell-free supernatant. The activity is produced only by growing cells and is destroyed by proteinase K and pronase E, the inhibitory properties of the strain and its secretory products being maintained in the presence of physiological concentrations of human bile and human gastric juice. The strain exhibits a broad spectrum of activity against bacteria including Listeria, Staphyloccocus including methocillin resistant St. aureus (MRSA), and Bacillus, but does not inhibit many closely related lactobacilli. An antimicrobial agent is obtained from the strain which has bacteriocin-like properties.
Cette souche de Lactobacillus salivarius, isolée à partir du tractus gastro-intestinal humain lavé et réséqué, inhibe une large gamme de micro-organismes du type Gram positif et Gram négatif et secrète un produit possédant une activité antimicrobienne dans un surnageant dépourvu de cellules. L'activité est produite seulement par les cellules croissantes et est détruite par la protéinase K et la pronase, les propriétés inhibitrices de la souche et les produits sécrétoires de celle-ci étant conservés en présence de concentrations physiologiques de bile et de suc gastrique humains. La souche de l'invention démontre un large spectre d'activité contre des bactéries, à savoir Listeria, Staphylococcus, notamment St. aureus résistant à la méthocilline, et Bacillus, mais n'inhibe pas nombre de Lactobacillus apparentés de façon proche à ceux-ci. L'invention concerne également un agent antimicrobien que l'on obtient à partir de cette souche et qui possède des propriétés du type bactériocine.
Collins John Kevin
O'sullivan Gerald Christopher
O'sullivan Marian Mary Geraldine
Thornton Gerardine Mary
Enterprise Ireland Trading As Bioresearch Ireland
Osler Hoskin & Harcourt Llp
University College Cork
University College Cork - National University Of Ireland Cork
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