A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/42 (2006.01) G01N 33/548 (2006.01) G01N 33/564 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2086605
2086605 9221031 PCTABS00017 In a procedure for detecting free or complexed anti-IgE autoantibodies, samples, especially human blood, are contacted and incubated with IgE material in form of IgE-antibodies, IgE peptides or recombinant IgE fragments bound on a solid carrier. The procedure can be carried out as a direct assay, as a sandwich assay or as a competitive assay. The procedure is useful in a method for preparing anti-allergic human anti-IgE antibodies having therapeutic blocking activities in allergic diseases. In this method a human body fluid having a content of anti-IgE autoantibodies is selected according to the above procedure and the immunoglobulin in the fluid is concentrated, preferably by alcohol fractionation or by ion exchange chromatography. For obtaining pure anti-IgE autoantibodies, they are isolated from the concentrated product by affinity chromatography. The anti-IgE antibodies and complexes thereof are useful as active components in pharmaceutical compositions for the treatment of allergic diseases. The formation of auto-anti-IgE antibodies can be induced in vivo by IgE-peptides or recombinant IgE fragments.
de Weck Alain
Robic
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