Procedure for isolating and purifying radioactive ligated...

Details Procedure for isolating and purifying radioactive ligated... Procedure for isolating and purifying radioactive ligated...

C - Chemistry, Metallurgy

01

G

167/101, 167/47

C01G 47/00 (2006.01) A61K 51/12 (2006.01)

Patent

CA 1287576

PROCEDURE FOR ISOLATING AND PURIFYING RADIOACTIVE LIGATED RHENIUM PHARMACEUTICALS AND USE THEREOF AND KIT ABSTRACT A sterile pyrogen free Re186 or Re188 radiopharmaceutical is prepared by reducing radio- active perrhenate in the presence of a bone seeking ligand to form a solution including complexed Re-ligand compound together with impurities such as uncomplexed perrhenate, ReO2 and free ligand. The radiopharmaceutical is obtained by a low pressure purification method. The solution is added to a separation column, preferably an ion exchange column, and a first portion is eluted and discarded. The radiopharmaceutical is collected in a second eluted portion defined as having 25-85% of the activity of the Re on the column, less than 10% unligated perrhenate and less than 1% ReO2. This can be used as is to image and treat metastatic bone lesions. A simple kit is also disclosed.

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