A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 1/02 (2006.01)
Patent
CA 2067134
This invention provides an improved method for prolonging the shelf life of transfusible red blood cells by decreasing the effective osmolality of the suspending solution and increasing the intracellular pH of the cells prior to storage thereof. This invention also provides methods whereby the intracellular pH may be increased. These methods include collecting the cells in an anti-coagulant at pH 7.0 or higher and/or washing, diluting or resuspending the cells prior to storage thereof in a biologically compatible buffered solution that contains at least one non-penetrating or substantially non-penetrating anion or non-electrolyte and is substantially free of chloride ions.
Procédé amélioré de prolongation de la durée de conservation de globules rouges pouvant être transfusés, consistant à diminuer l'osmolalité effective de la solution en suspension, et à augmenter le pH intracellulaire des cellules avant leur stockage. L'invention concerne également des procédes permettant d'aumgenter le pH intracellulaire. Ces procédés consistent à collecter les cellules dans un anticoagulant à un pH de 7,0 ou plus et/ou à laver, à diluer ou à remettre en suspension les cellules avant de les stocker dans une solution tamponnée biologiquement compatible, laquelle contient au moins un anion ou un non-électrolyte non pénétrant ou sensiblement non pénétrant, et est exempte d'ions de chlorure.
Hornblower Marne
Meryman Harold T.
Syring Ralph L.
Gowling Lafleur Henderson Llp
The American National Red Cross
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