Procedure for the obtainment of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 307/56 (2006.01) A01N 43/08 (2006.01) A61K 31/345 (2006.01)

Patent

CA 2147594

It is proposed a process for the obtainment and purification of 1-(5-bromofur- 2-yl) -2-bromo-2-nitroethene in one step of reaction from 1-(fur-2-yl)-2- nitroethene, with adequate level of yield and high purity which guarantees its use as an active principle in the medical and pharmaceutical industry (human and veterinary). The product has proven to be effective in "in vitro" assays both in laboratory animals and in humans against several types of gram negative and positive bacteria, higher bacteria, scotobacteria, budding monomorphic fungi and filamentous monomorphic fungi. The microcide action of the product, as an active principle in several development formulations for human and veterinary use for the treatment of diverse affections, is supported through various illustrative examples.

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