Procedure for the preparation of dioxopenicillanic acid...

C - Chemistry – Metallurgy – 07 – D

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C07D 499/04 (2006.01) C07D 277/60 (2006.01) C07D 499/00 (2006.01) C07D 499/86 (2006.01)

Patent

CA 2299959

The present invention provides a process for the preparation of dioxopenicillanic acid derivatives and its pharmaceutically acceptable salts with general Formula I, wherein, R is hydrogen, and alkyl group containing 1 to 5 carbon atoms, or a residue of type -CH2R', wherein R' is a hydrogen, halogen or a p-toluensulfonyl group. These products are prepared by treatment of the compunds of general Formula II, wherein R is as previously defined and X may be hydrogen or bromine, with a metallic reagent constituted by a mixture or alloy of copper and/or cobalt and/or manganese with iron and/or nickel in an aqueous/organic medium. These compounds are useful as inhibitors of beta- lactamase. <see Formula I>

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