A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/095 (2006.01) A61K 39/09 (2006.01) C08B 37/00 (2006.01) C07K 1/14 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2316975
A procedure to isolate large quantities of capsular polysaccharides (CPS) from culture supernatants as well as bacterial cells of gram-negative and gram-positive bacteria using base extraction is described. The procedure is simple, rapid, reproducible and applicable to a variety of bacterial species. The method also yields novel CPS characterized by their lack of covalent attachment to extraneous peptidoglycan. Vaccines and methods of immunization against bacterial infection using the CPS obtained by the process of the invention are also disclosed.
L'invention se rapporte à une procédure permettant d'isoler de grandes quantités de polysaccharides capsulaires (CPS) à partir de surnageants de culture ainsi que des cellules bactériennes de bactéries gram négatives et gram positives au moyen d'une extraction de base. Cette procédure est simple, rapide, susceptible d'être reproduite et applicable à une variété d'espèces bactériennes. Elle produit de nouveaux CPS qui se caractérisent par leur absence de liaison covalente à du peptidoglycane extérieur. L'invention se rapporte également à des vaccins et à des méthodes d'immunisation contre les infections bactériennes utilisant les CPS obtenus conformément à la procédure décrite ci-dessus.
Blake Milan
Michon Francis
Baxter Healthcare S.a.
North American Vaccine Inc.
Smart & Biggar
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