Process

Details Process Process

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01)

Patent

CA 2574362

The present disclosure relates to an improved process for the preparation of enantiomerically enriched alcohols of Formula (I), from the corresponding ketone of Formula (II), by asymmetric transfer hydrogenation, using a hydrogen donor, catalyzed by a ruthenium or rhodium complex of an optically active N- sulfamoyl-1,2-diamine. R is as defined herein.

L'invention concerne une nouvelle forme, à l'état solide, d'un dérivé de benzènesulfonamide pharmacologiquement actif. L'invention concerne également un procédé de préparation de cette nouvelle forme, ainsi que les compositions pharmaceutiques la contenant, en vue de leur utilisation pour le traitement ou la prévention d'états inflammatoires douloureux.

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