Process

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2527680

The invention relates to a set of isolated marker genes comprising at least one gene identified as having differential expression as between patients who are responders and non responders to an erbB receptor tyrosine kinase inhibitor; said gene set comprising one or more genes selected from at least the group consisting of the (51) genes listed herein including gene-specific oligonucleotides derived from said genes; and uses of sauch sets in diagnostic applications.

L'invention porte sur un ensemble de gènes marqueurs isolés comprenant au moins un gène identifié pour avoir une expression différentielle entre des patients qui sont répondants et non répondants à un inhibiteur de la tyrosine kinase du récepteur erbB. Cet ensemble de gènes comprend un ou plusieurs gènes sélectionnés dans au moins le groupe comprenant les (51) gènes listés constitués d'oligonucléotides spécifiques de gènes et dérivés de ces gènes. L'invention porte également sur l'utilisation de ces ensembles de gènes dans des applications diagnostiques.

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