Process

Details Process Process

C - Chemistry, Metallurgy

07

D

C07D 317/60 (2006.01) C07C 69/734 (2006.01) C07D 213/55 (2006.01) C07D 221/04 (2006.01) C07D 233/38 (2006.01) C07D 263/26 (2006.01) C07D 311/20 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 407/04 (2006.01) C07D 407/06 (2006.01) C07D 413/06 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2236929

Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S,2R,3S)-3-[2-(2-hydroxyeth-1- yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2- carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S,2R,3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4- methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.

Procédé perfectionné pour la préparation de dérivés de cyclopentane aromatiques à anneaux condensés. De préférence, les composés préparés selon ce procédé sont les carboxylates d'indane et les dérivés de cyclopentano[b]pyridine. Plus préférablement, les composés préparés selon ce procédé sont l'acide (+)(1S,2R,3S)-3-[2-(2-hydroxyéth-1-yloxy)-4-méthoxyphényl]-1-(3,4-méthylènedioxyphényl)-5-(prop-1-yloxy)indane-2-carboxylique et ses sels pharmaceutiquement acceptables, et l'acide (+)(1S,2R,3S)-3-(2-carboxyméthoxy-4-méthoxyphenyl)-1-(3,4-méthylènedioxyphényl)-5-(prop-1-yloxy)indane-2-carboxylique et ses sels pharmaceutiquement acceptables. On a également prévu de nouveaux intermédiaires utilisables dans la préparation de ces composés.

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