Process and apparatus for removal of dna and viruses

B - Operations – Transporting – 01 – D

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Details

B01D 25/26 (2006.01) A61L 2/00 (2006.01) A61L 2/02 (2006.01) B01D 61/14 (2006.01) B01D 61/18 (2006.01) B01D 67/00 (2006.01) B01D 69/12 (2006.01) B01D 71/10 (2006.01)

Patent

CA 2084873

2084873 9200132 PCTABS00010 A single filtration device (12) containing coated filter membranes (32, 38, 62, 68) and absolute pore filters (34, 36, 64, 66) is provided in which the membranes (32, 38, 62, 68) and absolute pore filters (34, 36, 64, 66) are present in two sections (30, 60) of the filter device. The filter device (12) will remove viruses, as modeled by type-C Xenotropic retrovirus, with an efficiency of at least 4.6 x 105; remove DNA from levels of 10 µg/sample to levels below 10 picograms per 500 mg sample of monoclonal antibody; and will remove at least 97 % of some bacterial endotoxins.

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