Process and apparatus for the production of bi-212 and a use...

Details Process and apparatus for the production of bi-212 and a use... Process and apparatus for the production of bi-212 and a use...

C - Chemistry, Metallurgy

01

G

C01G 29/00 (2006.01) A61K 51/00 (2006.01) A61K 51/12 (2006.01) B01D 59/30 (2006.01) G21G 4/08 (2006.01)

Patent

CA 2261772

A process for producing substantially radio-impurity-free Bi-212 is disclosed. An acidic feed solution containing Pb-212 is contacted with an extraction medium to bind the Pb-212 thereto. The extraction medium is rinsed with a second acid solution to remove impurities therefrom, leaving a substantially impurity-free Pb-212-laden extraction medium. The Pb-212 grows on the extraction medium to form Bi-212 by radioactive decay. The Bi-212 is then eluted from the extraction medium with an acid solution to form a substantially radio-impurity-free Bi-212 acid solution. An apparatus for carrying out this process and a process for the therapeutic use thereof are also disclosed.

L'invention concerne un procédé, destiné à produire du Bi-212 sensiblement exempt de radio-impuretés. Une solution d'alimentation acide contenant du Pb-212 est mise en contact avec un milieu d'extraction en vue de lier le Pb-212 à celle-ci. Ce milieu d'extraction est rincé au moyen d'une deuxième solution acide afin d'en retirer des impuretés, laissant un milieu d'extraction chargé de Pb-212 sensiblement exempt d'impuretés. Ce Pb-212 croît sur le milieu d'extraction pour former du Bi-212 par désintégration radioactive. Ce Bi-212 est ensuite élué à partir du milieu d'extraction avec une solution acide, pour former une solution acide de Bi-212 sensiblement exempte de radio-impuretés. Un appareillage permettant de mettre en oeuvre ce procédé et un procédé destiné à l'utilisation thérapeutique de celui-ci son également décrits dans cette invention.

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