Process and arrangement for producing particles utilizing...

B - Operations – Transporting – 01 – J

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B01J 2/02 (2006.01) B01J 3/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2707568

A method for producing particles of predetermined sized and/or morphology of a substance in a production arrangement comprising the steps of: i) mixing within a spray nozzle and under flow conditions a stream of a liquid solution in which the substance is dissolved with a stream of a fluid, and ii) passing the mixture in the form of a spray through a spray outlet of the nozzle into a particle collecting container, and iii) separating and collecting within the container the particles. The characteristic feature is that the solvent is a liquid and the fluid is an aqueous liquid in a subcritical state. Preferred nozzles have two coaxial internal transport conduits. One aspect is a production arrangement that can be used in the method. Its characteristic features are functions for a) recycling fluid used in the process, b) for including a make-up agent in the fluid stream, and/or increasing production by paralleling particle formation.

L'invention concerne un procédé de production de particules à base d'une substance ayant une taille et/ou morphologie prédéterminée dans un dispositif de production comprenant les étapes suivantes : i) mélange à l'intérieur d'une buse de pulvérisation et dans des conditions d'écoulement d'une solution liquide dans laquelle la substance est dissoute dans un fluide en écoulement, et ii) introduction du mélange sous la forme de fines gouttelettes via l'orifice de pulvérisation de la buse dans un récipient de collecte de particules, et iii) séparation et collecte des particules contenues dans le récipient. Le trait caractéristique est que le solvant est un liquide et le fluide est un liquide aqueux à l'état subcritique. Les buses préférées ont deux conduits de transport internes coaxiaux. Selon un aspect de l'invention, un dispositif de production peut être utilisé dans le procédé. Ses traits caractéristiques sont des fonctions pour a) recycler le fluide utilisé dans le procédé, b) ajouter un agent d'appoint dans le fluide en écoulement et/ou augmenter la production par formation de particules en parallèle.

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