Process and intermediate for preparation of donepezil

Details Process and intermediate for preparation of donepezil Process and intermediate for preparation of donepezil

C - Chemistry, Metallurgy

07

D

C07D 211/32 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2635550

The invention relates to new compounds of formula (III): wherein R is a C1-C4 linear or branched alkyl group. The invention also relates to new compounds of formula (IV) wherein M is a metal. The invention also relates to methods of making compounds of formulas (III) and (IV) and to methods of making donepezil and pharmaceutically acceptable salts thereof, such as donepezil hydrochloride, using the compounds.

L~invention concerne de nouveaux composé de formule (III) : R représentant un groupement alkyle linéaire ou ramifié en C1-C4. L~invention concerne également de nouveaux composés de formule (IV), M représentant un métal. L~invention concerne également des procédés de fabrication de composés de formules (III) et (IV) et des procédés de fabrication de donépézil et de ses sels pharmaceutiquement acceptables, tels que l~hydrochlorure de donépézil, en utilisant les composés.

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