C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2143971
A process for the preparation of 1-(4-amino-6,7-dimethoxy-2- quinazolinyl)-4(2-tetrahydrofuroyl)piperazine hydrochloride (terazosin hydrochloride dihydrate comprises the steps of reacting 4-amino-2-chloro-6,7- dimethoxy-quinazoline with N-(2-tetrahydrofuroyl)piperazine in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydro- furoyl)piperazine hydrochloride (Form IV) and thereafter converting the product of that step to 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4(2-tetrahydrofuroyl)- piperazine hydrochloride dihydrate.
Méthode pour préparer le chlorhydrate de 1-(4-amino-6,7-diméthoxy-2- quinazolinyl)-4(2-tétrahydrofuroyl)pipérazine (chlorhydrate de térazosine dihydraté), consistant à faire réagir la 4-amino-2-chloro-6,7- diméthoxyquinazoline avec la N-(2-tétrahydrofuroyl)pipérazine dans un solvant organique polaire anhydre, en l'absence d'un additif épurateur acide, pour l'obtention de chlorhydrate de 1-(4-amino-6,7-diméthoxy-2-quinazolinyl)-4-(2-tétrahydrofuroyl)pipérazine anhydre (forme IV), puis en convertissant le produit ainsi obtenu en chlorhydrate de 1-(4-amino-6,7-diméthoxy-2-quinazolinyl)-4(2-tétrahydrofuroyl) pipérazine dihydraté.
Heitmann Wayne R.
Henry Rodger F.
Horrom Bruce W.
Mannino Anthony
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
Process and intermediate for the preparation of terazosin... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process and intermediate for the preparation of terazosin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process and intermediate for the preparation of terazosin... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1459764