Process and intermediates for grf peptide

Details Process and intermediates for grf peptide Process and intermediates for grf peptide

C - Chemistry, Metallurgy

07

K

530/7.1

C07K 14/60 (2006.01)

Patent

CA 1339631

Disclosed herein is an improved process for preparing the amidated fragment of growth hormone releasing factor containing the first 29 amino acids of the N-terminal portion. The process is based on a modified solid phase peptide synthesis using highly purified key intermediates represented by the formulae Tyr-Arg-Lys-Val-Leu-Gly and Gln-Leu-Ser-Ala-Arg-Lys-Leu.

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