Process and intermediates for lh-rh peptides

Details Process and intermediates for lh-rh peptides Process and intermediates for lh-rh peptides

C - Chemistry, Metallurgy

07

K

530/1, 530/17.02

C07K 17/02 (2006.01) C07K 1/00 (2006.01) C07K 7/23 (2006.01)

Patent

CA 1335403

Disclosed herein is an improved process, and inter- mediates therefor, for preparing gonadorelin and certain analogs. The key intermediate is the protected nonapeptide Pyr(W1)-His(W2)-Trp(W3)-Ser(W4)-Tyr(W5)-X1-Leu-Arg(W6)-Pro- OH wherein W1 to w6 inclusive are protective groups and X is Gly, D-2-(naphthylalanyl) or D-Trp(W7) wherein W7 is a protective group.

566195

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