Process and intermediates for preparing anti-cancer compounds

Details Process and intermediates for preparing anti-cancer compounds Process and intermediates for preparing anti-cancer compounds

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01)

Patent

CA 2427221

Disclosed are methods for preparing compounds of the formula 9 Image and the pharmaceutically acceptable salts and solvates thereof, wherein R6 is alkyl or alkoxyalkyl; R7 is optionally substituted alkyl or optionally substituted alkylaryl; each R8, R9 and R10 are independently H, alkyl, halo, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido,-OR11,-C(O)R11,-C (O)OR11, -NR12C(O)OR14,-OC(O)R11,-NR12SO2R14,-SO2NR11R12,-NR12C(O)R11, -C(O)NR11R12,-NR11R12, -S(O)j aryl, -S(O)j alkylaryl, -S(O)j alkyl, aryl, arylalkyl, aryloxy, arylalkoxy, arylamino, arylalkylamino, arylalkyl (alkyl) amino, heterocyclic or heterocyclic-alkyl, wherein j is 0 to 2; R11 is H, alkyl, aryl, arylalkyl, heterocyclic or heterocyclic-alkyl; R12 is H or unsubstituted alkyl and R14 is alkyl, aryl, arylalkyl, heterocyclic or heterocyclic-alkyl; and wherein the alkyl, aryl and heterocyclic groups may be substituted and the aryl and heterocyclic groups may be fused to an aryl, saturated cyclic group or heterocyclic group; and R15 is H, alkyl, aryl or alkylaryl. The foregoing compounds are useful in the treatment of hyperproliferative disorders, such as cancers, in mammals.

Affiliated with

Also associated with

Rating

Process and intermediates for preparing anti-cancer compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process and intermediates for preparing anti-cancer compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process and intermediates for preparing anti-cancer compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1470432