Process and intermediates for producing glucagon

Details Process and intermediates for producing glucagon Process and intermediates for producing glucagon

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2024855

Disclosed herein is an improved process for preparing the nonacosapeptide glucagon. The process comprises the serial coupling of two highly purified fragments, glucagon(15-22) and glucagon(7-14) fragments, to a modified glucagon(23-29) fragment having a benzhydrylamine type resin attached to the .omega.-carboxyl of Asp at position 28.

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