Process and intermediates for production of benzothiazine...

Details Process and intermediates for production of benzothiazine... Process and intermediates for production of benzothiazine...

C - Chemistry, Metallurgy

07

D

260/243.21

C07D 279/02 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1179340

ABSTRACT OF THE DISCLOSURE A process for the preparation of a novel compound of formula Image (I) wherein R is hydrogen, benzyl or alkyl having from one to three carbon atoms; R1 is benzyl or alkyl having from one to four carbon atoms; and Z1 taken together with - =N- forms a heterocyclic group Z, where Z is 2-pyridyl, alkyl substituted-2-pyridyl, 2- thiazolyl, 2-thiazolyl substituted by one or two alkyl groups, or 5-alkyl-3-isoxazolyl, each alkyl having from one to four carbon atoms, which comprises contacting an ester of the formula Image wherein R1 is benzyl or alkyl having from one to four carbon atoms, with an amine of the formula ZNH2 in the presence of reaction inert organic solvent at a temperature of from about 50-110°C; and a novel process utilizing the compounds of formula (I) as intermediates for production of known anti-inflammatory agents of the formula Image (IV)

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