Process and intermediates for pyridazinone antidiabetic agents

Details Process and intermediates for pyridazinone antidiabetic agents Process and intermediates for pyridazinone antidiabetic agents

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01)

Patent

CA 2472331

The present invention relates to a process for preparing pyridazinone aldose reductase inhibitors which are useful in the prevention and/or treatment of diabetic complications such as diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, diabetic cardiomyopathy, diabetic microangiopathy and diabetic macroangiopathy in mammals. The invention also relates to novel intermediates useful in preparing those aldose reductase inhibitors.

Cette invention concerne un procédé de préparation d'inhibiteurs pyridazinone d'aldose réductase, lesquels inhibiteurs contribuent à la prévention et/ou au traitement de complications dues au diabète, telles que la neuropathie diabétique, la rétinopathie diabétique, la néphropathie diabétique, la cardiomyopathie diabétique, la microangiopathie diabétique et la macroangiopathie diabétique chez les mammifères. Cette invention porte également sur de nouveaux intermédiaires servant à préparer ces inhibiteurs d'aldose réductase.

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