Process and intermediates for sorbinil

Details Process and intermediates for sorbinil Process and intermediates for sorbinil

C - Chemistry, Metallurgy

07

D

260/356.1, 260/3

C07D 311/68 (2006.01) C07D 491/107 (2006.01)

Patent

CA 1245667

ABSTRACT OF THE DISCLOSURE Chiral sorbinil intermediates of the formula Image (wherein R is hydrogen or benzyloxycarbonyl and Y is hydroxy or amino) are useful as intermediates for the preparation of sorbinil. The compound of the formula in which R is benzyloxycarbonyl and Y is amino can be treated with a strong base to convert to sorbinil of the formula: Image The chiral intermediates may be produced by a process which involves combining racemic 6-fluoro-4-(benzyloxycarbonylamino)- chroman-4-carboxylic acid with 1-(-)-alpha-methylbenzylamine and then resolving the resulting salt.

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