Process and intermediates for the preparation of...

Details Process and intermediates for the preparation of... Process and intermediates for the preparation of...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) B01J 19/24 (2006.01) C07C 51/347 (2006.01) C07C 59/56 (2006.01) C07C 69/732 (2006.01) C07C 229/34 (2006.01) C07C 229/36 (2006.01) C07C 271/22 (2006.01) C07C 303/28 (2006.01) C07C 309/65 (2006.01) C07D 261/18 (2006.01) C12M 1/12 (2006.01) C12P 1/00 (2006.01) C12P 7/42 (2006.01) C12P 17/14 (2006.01)

Patent

CA 2376509

Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula (I), particulary (I'), key intermediates useful in those synthetic routes, as well as a continuous membrane reactor useful for those synthetic routes. These compounds of formula (I), as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.

L'invention concerne des voies de synthèse efficaces dans la préparation d'inhibiteurs de protéase de rhinovirus de la formule (I), des intermédiaires clés utiles dans ces voies de synthèse, ainsi qu'un réacteur à membrane continue utile pour ces voies de synthèse. Ces composés de la formule (I), de même que des compositions pharmaceutiques contenant ces composés, sont adaptés au traitement de patients ou hôtes infectés par un ou plusieurs picornavirus.

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