C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/27 (2006.01) C07B 57/00 (2006.01) C07C 45/58 (2006.01) C07C 49/753 (2006.01) C07C 51/487 (2006.01) C07C 61/35 (2006.01) C07C 69/743 (2006.01) C07C 309/73 (2006.01) C07D 473/00 (2006.01) C07D 473/18 (2006.01)
Patent
CA 2079496
GY22 ABSTRACT Process And Intermediates For The Preparation Of An Antiviral Agent Racemic Feist's acid is treated with (R)-(+)-a- methylbenzylamine to yield (lR-trans)-3-methylene- cyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzyl- amine (1:1) salt. This salt can then be converted to (lR-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]- 2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-1,9- dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
Godfrey Jollie D. Jr.
Kissick Thomas P.
Mueller Richard H.
Singh Janak
Godfrey Jollie D. Jr.
Kissick Thomas P.
Mueller Richard H.
Osler Hoskin & Harcourt Llp
Singh Janak
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