Process and intermediates for the preparation of the...

Details Process and intermediates for the preparation of the... Process and intermediates for the preparation of the...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) C07D 209/00 (2006.01) C07D 333/00 (2006.01) C07D 333/36 (2006.01)

Patent

CA 2500145

A process for preparing a compound of formula (I) where R4 and R5are as defined in the specification; and R6 is hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where R4, R5and R6 are as defined in relation to formula (I) and R7is a nitrogen-protecting group, and removing protecting group R7-, and thereafter if desired or necessary, removing any protecting group R6 to obtain the corresponding carboxylic acid. Novel intermediates and the use of the products in the preparation of pharmaceutical compounds is also described and claimed.

L'invention concerne un procédé de préparation d'un composé de formule (1), dans laquelle R?4¿ et R?5¿ sont tels que définis dans la description, et R?6¿ représente hydrogène ou un groupe de protection. Ledit procédé comprend la cyclisation d'un composé de formule (II), dans laquelle R?4¿, R?5 ¿et R?6¿ sont définis par rapport à la formule (I) et R?7¿ représente un groupe protecteur d'azote. Ledit procédé comprend également l'élimination du groupe de protection R?7¿, puis, si nécessaire, l'élimination du groupe de protection R?6¿, de façon à obtenir l'acide carboxylique correspondant. L'invention concerne, en outre, de nouveaux produits intermédiaires et l'utilisation des produits dans la préparation de composés pharmaceutiques.

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