C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/26 (2006.01) C07D 471/10 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2736195
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis- (trifluoromethyl)phenyl)-ethoxy}--nnethyl]-8-phenyl-1,7-diaza- spiro[4.5]decan-2-one compounds, which maybe used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes. IM=102123
Linvention se rapporte à un nouveau procédé pour effectuer la synthèse de composés de 8-[{1-(3,5-bis(trifluorométhyl)phényl)éthoxy}méthyl]-8-phényl-1,7-diaza-spiro[4.5]décan-2-one qui peut être utilisé par exemple en tant que composés inhibiteurs de NK-1 dans des intermédiaires pour préparations pharmaceutiques utiles dans ledit procédé et linvention se rapporte également aux procédés de préparation desdits intermédiaires. Linvention se rapporte enfin à un procédé pour éliminer les métaux de complexes métalliques carbènes N-hétérocycliques.
Castellanos Louis Peter
Chen Yuyin
Cui Jian
Fu Xiaoyong
Mergelsberg Ingrid
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Opko Health Inc.
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