Process and intermediates for the synthesis of...

Details Process and intermediates for the synthesis of... Process and intermediates for the synthesis of...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01)

Patent

CA 2661737

This application discloses a novel process to synthesize (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives, and intermediates useful in the synthesis thereof. The subject (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives are useful as cyclin-dependent kinase inhibitor compounds (CDK inhibitors) in pharmaceutical preparations.

Cette invention concerne un nouveau procédé servant à la synthèse de dérivés de (3-alkyl-5-pipéridin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino, ainsi que des intermédiaires utilisés dans la synthèse de ceux-ci. Les dérivés de (3-alkyl-5-pipéridin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino de cette invention servent de composés inhibiteurs de kinase dépendante des cyclines (inhibiteurs de CDK) dans des préparations pharmaceutiques.

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