Process and intermediates for the synthesis of...

Details Process and intermediates for the synthesis of... Process and intermediates for the synthesis of...

C - Chemistry, Metallurgy

07

D

C07D 211/38 (2006.01) C07D 471/10 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2682221

This application discloses a process to synthesize 8-({1-(3,5-Bis- (trifluoromethyl)phenyl)-ethoxy)-methyl]-8-pheny-1.7-diaza-s.rho.iro[4.5]decan-2-one comprising reacting a compound of the Formula 27a-sulfonate with zinc in the presence of acetic acid.

La présente invention concerne un nouveau procédé de synthèse de composés de 8-[{1-(3,5-bis-(trifluorométhyl)phényl)-éthoxy}-méthyl]-8-phényl-1,7-diaza-spiro[4.5]décan-2-one. Ces composés peuvent être utilisés, par exemple, en tant que composés inhibiteurs de NK-1 dans des préparations pharmaceutiques.

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