Process and methods for the preparation of gabapentin and...

Details Process and methods for the preparation of gabapentin and... Process and methods for the preparation of gabapentin and...

C - Chemistry, Metallurgy

07

C

C07C 227/12 (2006.01) C07C 227/22 (2006.01) C07C 233/36 (2006.01) C07D 209/54 (2006.01)

Patent

CA 2598816

The invention provides a process for preparing gabapentin and its intermediates. The process generally involves treating gabapentin lactam with an aqueous solution of hydrobromic acid to yield gabapentin hydrobromide salt as an intermediate, which can be isolated by filtration. The gabapentin hydrobromide salt can then be hydrolyzed with a base, such as an organic amine, to yield gabapentin that can be isolated by filtration.

L'invention concerne la préparation d'acide 2-chloro-4-fluoro-5-nitrobenzoïque et de dérivés de cet acide, par nitration de 2-chloro-4-fluorobenzotrichlorure, et la transformation du nouveau produit intermédiaire de synthèse ainsi obtenu en forme acide ou en dérivés de cet acide. L'invention concerne également la transformation de produits intermédiaires de synthèse du benzotrichlorure en dérivés de benzotrifluorure correspondants.

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