C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/15, 167/37,
C12Q 1/48 (2006.01) C12Q 1/50 (2006.01) G01N 33/70 (2006.01)
Patent
CA 1160942
ABSTRACT The present invention provides a process for the determination of creatine kinase-MB in serum by the immunological elimination of subunit M and measurement of subunit B by methods known for the determination of creatine kinase, wherein subunit M is eliminated by adding to the test sample monovalent fragments obtained from antibodies against subunit M by proteolytic splitting under reducing conditions, whereafter subunit B is measured by methods known for the determination of creatine kinase. The present invention also provides a reagent for the determination of creatine kinase-MB, comprising a system for the determination of creatine kinase-MB and an agent for the immunological elimination of subunit M of the creatine kinase, the agent for the immunological elimination consisting of monovalent fragments of anti- bodies against creatine kinase-MM.
346572
Gruber Wolfgang
Lenz Helmut
Linke Hans-Ralf
Looser Siegfried
Boehringer Mannheim G.m.b.h.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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