Process and uses for 4,5-dihydrogeldanamycin and its...

Details Process and uses for 4,5-dihydrogeldanamycin and its... Process and uses for 4,5-dihydrogeldanamycin and its...

C - Chemistry, Metallurgy

12

P

C12P 17/10 (2006.01) A61K 31/395 (2006.01) C07D 225/06 (2006.01)

Patent

CA 2127457

2127457 9314215 PCTABS00024 A process for the fermentation and isolation of compounds (I) and (II), members of the ansamycin benzoquinone antibiotics family, having formulae (I) and (II), as well as the chemical synthesis of compound (II) from coumpound (I) are disclosed in the present invention. The compounds of the present invention are useful against proliferative disorders including, but not limited to, cancer in mammals, especially humans. The compounds of the present invention are also expected to be useful against certain microorganisms, and have utility as immunosuppressive agents against autoimmune diseases.

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