C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/271.5, 260/2
C07D 215/18 (2006.01) C07D 215/233 (2006.01) C07D 455/04 (2006.01)
Patent
CA 1153378
Abstract of the Disclosure An improved process for preparing the anti- microbial compound flumequine is disclosed. The first step of the process comprises reacting 4-fluoroaniline with crotonaldehyde under acidic conditions at a temperature between 50 and 60°C. in the second step, the product of the first step is treated to provide a mixture of 6-fluoroquinaldine and 6-fluorotetrahydro- quinaldine. This mixture is then treated with base in the presence of weak acid followed by reducing to provide 6-fluorotetrahydroquinaldine. This compound is then treated according to known procedures to form flumequine.
369748
Hedberg Kirk G.
Leir Charles M.
Riker Laboratories Inc.
Robic Robic & Associes/associates
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