B - Operations – Transporting – 02 – C
Patent
B - Operations, Transporting
02
C
B02C 17/14 (2006.01) A61K 9/14 (2006.01) B02C 17/20 (2006.01)
Patent
CA 2450907
A process is described for the activation (increase in solubility and bioavailability) of drugs. The process, carried out in a vibrational mill, is characterised by the use of given proportions between the physical mixture made up of drug and pharmaceutical carrier and the empty volume among the grinding means contained inside the mill. The process leads to obtaining powders for pharmaceutical use in which the drug has a high and constant degree of activation; this result is obtainable irrespective of the nature of the drug and carrier used, and of their weight ratio.
L'invention concerne un procédé servant à activer des médicaments, à savoir augmenter leur solubilité et biodisponibilité. Ce procédé, mis en application dans un broyeur à vibrations, consiste à utiliser des proportions données entre le mélange physique constitué par le médicament et un véhicule pharmaceutique et le volume de vide parmi les éléments broyeurs contenus à l'intérieur du broyeur. Ce procédé permet d'obtenir des poudres à usage pharmaceutique dans lesquelles le principe médicamenteux est activé à un degré élevé et constant. On peut obtenir ce résultat indépendamment de la nature du médicament et de celle du véhicule et, également, indépendamment de leur rapport de poids.
Bresciani Massimo
Dobetti Luca
Eurand Pharmaceuticals Ltd.
Marks & Clerk
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