Process for .alpha.-c-alkylation of the 8-acyl group on...

Details Process for .alpha.-c-alkylation of the 8-acyl group on... Process for .alpha.-c-alkylation of the 8-acyl group on...

C - Chemistry, Metallurgy

07

D

260/357.3, 260/4

C07D 309/30 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1287063

TITLE OF THE INVENTION PROCESS FOR .alpha.-C-ALKYLATION OF THE 8-ACYL GROUP ON MEVINOLIN AND ANALOGS THEREOF ABSTRACT OF THE DISCLOSURE A process for alkylating the alpha position of the 8-acyl side chain in mevinolin and analogs thereof is disclosed. The process proceeds with a single charge of base and alkyl halide to give products with a pharmaceutically acceptable purity.

571603

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