Process for asymmetric synthesis of optically active...

Details Process for asymmetric synthesis of optically active... Process for asymmetric synthesis of optically active...

C - Chemistry, Metallurgy

07

C

260/576.6

C07C 49/82 (2006.01) C07C 45/45 (2006.01) C07C 62/32 (2006.01) C07C 62/34 (2006.01) C07D 207/16 (2006.01) C07D 498/10 (2006.01)

Patent

CA 1089491

Abstract of the Disclosure: A process for asymmetric synthesis of optically active 2-alkanoyl-1,2,3,4-tetrahydro-2-naphthol compounds of the formula: Image from L-proline or its ester and the following carboxylic acid of the formula: Image or its reactive derivative through the following inter- mediary compounds in order: Image ; Image ; and Image . The compounds thus produced are useful as starting materials for the synthesis of anthracycline antibiotics which have anti-neoplastic activity.

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