C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 477/00 (2006.01) C07D 205/08 (2006.01) C07D 463/00 (2006.01) C07D 477/04 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2043939
X-8067 ABSTRACT 1-Carbapenam-2-one-3-carboxylic acid and 1-carba-3-hydroxy-3-cephem-4-carboxylic acid and esters thereof are provided by a process comprising a rhodium C2-C10 carboxylate catalyzed cyclization of an ester of a 4-(1-alkoxy- or 1-substituted alkoxy)-2-oxo-4- azetidinyl)-.alpha.-diazo-.beta.-ketobutyric acid and an ester of a 5-(1-alkoxy- or 1-substituted alkoxy-2-oxo-4- azetidinyl)-.alpha.-diazo-.beta.-ketovaleric acid respectively. The process is carried out in an inert organic solvent at a temperature between about 15° C and about 85° C. The 1-carba bicyclic .beta.-lactams are intermediates for preparing antibiotics.
Miller Marvin J.
Williams Matthew A.
Gowling Lafleur Henderson Llp
University Of Notre Dame Du Lac
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