Process for biophosphorylating organic compounds

Details Process for biophosphorylating organic compounds Process for biophosphorylating organic compounds

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 38/08 (2006.01) C07F 9/09 (2006.01) C07F 9/117 (2006.01) C07F 9/6533 (2006.01) C07F 9/655 (2006.01) C07H 19/01 (2006.01) C07K 7/06 (2006.01) C07K 7/56 (2006.01) C12P 9/00 (2006.01) C12P 17/14 (2006.01) C12P 17/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2093429

2093429 9206992 PCTABS00012 Described is a new microbial biophosphorylation process for regiospecifically phosphorylating the hydroxyl group, in a ''phosphate active'' hydroxyl containing organic compound, under biotransformation conditions utilizing the microorganism, Rhizopus oryzae) ATCC No. 11145. The phosphorylated compounds produced by the process include e.g., macrolide FK-506 type immunosuppressants which are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, kidney, lung and heart transplants. Other hydroxyl containing compounds, applicable in this process include rapamycin, echinocandins, HIV protease inhibitors, simvastatin and zearalenone.

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