Process for coating droplets or nanometric particles

Details Process for coating droplets or nanometric particles Process for coating droplets or nanometric particles

B - Operations, Transporting

01

J

B01J 13/02 (2006.01) A01N 25/28 (2006.01) A61K 9/51 (2006.01) B01J 13/22 (2006.01) C05G 5/00 (2006.01) C12N 11/02 (2006.01)

Patent

CA 2167681

The process comprises: (1) preparing a fine dispersion of droplets or particles which contain or are formed of a chemical or biologically active substance in a phase comprised of a solvent and a non solvent of the polymer forming the coating and optionally a surfactant or suspensor agent; (2) preparing a phase which contains the coat-forming polymer dissolved in a miscible solvent in any proportion with the prior dispersion; (3) mixing both phases continuously while maintaining constant the relationship between the phases and the mixture volume and simultaneously spraying the resultant mixture in an evaporation system with temperature and vacuum conditions which provide for the instantaneous evaporation of the solvent from the polymer, causing the deposition of the polymer around the particles or droplets. Application to pharmacy, medicine, cosmetics, veterinary, chemical industry, agriculture, etc.

Le procédé comprend: (1) la préparation d'une fine dispersion de gouttelettes ou de particules qui contiennent ou sont formées d'une substance chimique ou biologiquement active dans une phase composée d'un solvant et d'un non-solvant du polymère formant l'enrobage et éventuellement d'un tensioactif ou un agent suspenseur; (2) la préparation d'une phase qui contient le polymère formant l'enrobage dissous dans un solvant miscible dans une proportion quelconque avec la dispersion antérieure; (3) le mélange des deux phases en continu et tout en maintenant constante la relation entre les phases et le volume du mélange, et en pulvérisant simultanément le mélange obtenu dans un système d'évaporation dont les conditions de température et de vide sont telles qu'elles permettent l'évaporation instantanée du solvant du polymère, et donc le dépôt du polymère autour des particules ou gouttelettes. Application en pharmacie, médecine, cosmétique, dans le domaine vétérinaire, dans l'industrie chimique, en agriculture, etc.

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