Process for conversion of cyanopyridines to nicotinamides...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/81 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2511728

The present invention relates to an improved process for conversion of cyanopyridines to nicotinamides. More particularly the present invention relates to preparation of nicotinamides and isonicotinamides which finds its usage in the preparation of anti-TB drug i.e. isoniazid and as an intermediate of vitamin B12. The present invention also relates to a process for a catalyst useful for the preparation of nicotinamide and isonicotinamide.

L'invention concerne un procédé amélioré pour la conversion de cyanopyridines en nicotinamides. En particulier, l'invention concerne la préparation de nicotinamides et d'isonicotinamides utiles dans la préparation de médicaments contre la tuberculose, à savoir l'isoniazide, et en tant qu'intermédiaire de la vitamine B¿12?. L'invention concerne également un procédé pour un catalyseur, utile pour la préparation de nicotinamide et d'isonicotinamide.

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