C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/359.9
C07D 311/78 (2006.01) C07D 311/80 (2006.01)
Patent
CA 1090358
Abstract of the Disclosure This invention provides a novel process which comprises the reaction of an aluminum halide with a 2,7- dihydroxy-5-isopropylidene-9-substituted-2,6-methano- 3,4,5,6-tetrahydro-2H-1-benzoxocin in an organic solvent to effect cleavage of the pyran ring system with con- comitant recyclization to provide exclusively a 6a,10a- trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a- hexahydro-9H-dibenzo[b,d]pyran-9-one.
281751
Blanchard William B.
Ryan Charles W.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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