Process for converting 2,7-dihydroxy-5-isopropylidene-...

C - Chemistry – Metallurgy – 07 – D

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260/359.9

C07D 311/78 (2006.01) C07D 311/80 (2006.01)

Patent

CA 1090358

Abstract of the Disclosure This invention provides a novel process which comprises the reaction of an aluminum halide with a 2,7- dihydroxy-5-isopropylidene-9-substituted-2,6-methano- 3,4,5,6-tetrahydro-2H-1-benzoxocin in an organic solvent to effect cleavage of the pyran ring system with con- comitant recyclization to provide exclusively a 6a,10a- trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a- hexahydro-9H-dibenzo[b,d]pyran-9-one.

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