Process for converting 9-dihydro-13-acetylbaccatin iii into...

Details Process for converting 9-dihydro-13-acetylbaccatin iii into... Process for converting 9-dihydro-13-acetylbaccatin iii into...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2696856

Processes for the preparation of docetaxel and paclitaxel or analogs from 9- dihydro-13-acetylbaccatin III via key intermediates (4), (5), (6), (6'), (8) and (8') or via intermediate (12) as well as processes for the preparation of said intermediates are disclosed. Said processes involve, in particular, oxidation of the hydroxy group at C-10, reaction with side chain precursors and intramolecular isomerisation of the oxo at C-10 to produce the 9-oxo isomer. Paclitaxel and docetaxel are useful in the treatment of cancer. Formulae (I), (II), (III).

L'invention porte sur un procédé de préparation de docétaxel ou de paclitaxel, sur des intermédiaires utiles dans la préparation de docétaxel ou de paclitaxel, et sur des procédés de préparation d'intermédiaires utiles dans la préparation de docétaxel ou de paclitaxel.

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