Process for converting a cis-trans mixture of substituted...

Details Process for converting a cis-trans mixture of substituted... Process for converting a cis-trans mixture of substituted...

C - Chemistry, Metallurgy

07

C

C07C 251/24 (2006.01) C07B 55/00 (2006.01) C07C 249/02 (2006.01)

Patent

CA 2505797

A process for interconverting a mixture of cis-trans erythro-threo isomers of a compound of formula I into the substantially pure cis isomer. Cis isomers of formula I are usefull intermediates in the synthesis of cis isomers of benzamide piperidine compounds which exhibit activity as NK-1 receptor antagonists.

La présente invention a trait à un procédé d'interconversion d'un mélange d'isomères cis-trans érythro-thréo d'un composé de formule I en un isomère cis sensiblement pur. Les isomères cis de formule I sont des intermédiaires utiles dans la synthèse d'isomères cis de composés de benzamide pipéridine présentant une activité en tant qu'antagonistes de récepteur NK-1.

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